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Our B12 Self-Injection Kits include step by step instructions to ensure safe, intramuscular (IM) injection of vitamin B12
The honest position is this: there is no head-to-head human bioavailability trial telling you which route is superior for this specific molecule, so the best route is not a settled question
Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe
The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions