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When administered intravenously or through injection, the Vitamin B12 is not subject to gut absorption and the entire dosage administered is available to the body for use

The disadvantage is that lower doses become harder to measure accurately

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Functions as a for metabolic reaction required for synthesis of purines and pyrimidines: co-enzyme The reaction depends on methyl cobalamin as a co-factor and is also dependent on folate, in which the methyl group of methyltetrahydrofolate is transferred to homocysteine to form methionine and tetrahydrofolate

Stress and poor sleep do not directly lower levels, but they increase nutrient demand and can worsen symptoms of existing deficiencies