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The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis

*Correspondence: Ley Cody Smith, [email protected] These authors have contributed equally to this work and share first authorship ORCID: Ley Cody Smith, orcid.org/0000-0003-2388-4032 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These cytokines disrupt Sertoli cell tight junctions, reduce Leydig cell steroidogenic capacity, and induce germ cell apoptosis, collectively impairing the testicular microenvironment both structurally and functionally

Further studies with large sample size or better controls are needed

The Science BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids derived from a protective protein found naturally in human gastric juice