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10.1016/j.metabol.2010.03.010 56

It has been documented in a meta-analysis study and a systematic review that elevated levels of 8-OHdG in biological samples, such as urine, serum, or tissue, are indicative of increased oxidative stress (182, 183)

The decision between these compounds depends on research objectives, budget, availability, and tolerance profiles

For longer-term use broadly defined as more than three weeks NICE guidance highlights the need for: Gradual dose reduction to prevent adrenal insufficiency Bone protection with calcium, vitamin D, and potentially bisphosphonates if long-term use is anticipated Regular monitoring of blood pressure, blood glucose, and weight Steroid treatment cards patients on long-term steroids should carry a blue NHS Steroid Treatment Card to alert healthcare professionals in emergencies NHS Steroid Emergency Card patients at risk of adrenal crisis (e.g., those on prolonged or high-dose courses) should also carry a Steroid Emergency Card, as recommended by the MHRA (Drug Safety Update, 2020) [26] It is also worth noting that high-dose short courses or repeated courses of prednisolone may warrant tapering or additional monitoring based on clinical judgement, even if the individual course is less than three weeks

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