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This decline has systemic consequences

Abnormal levels affect menstrual cycles, fertility and can indicate pituitary tumors

Also, another randomized double-blind study compared the efficacy of 100 mg diclofenac sodium soft gel (with or without 100 mg caffeine) with placebo during migraine attacks

Ther Adv Chronic Dis (2016) 7:417

J Infect Dis 201(2):255263 Talreja D et al (2014) Pathogenicity of ocular isolates of Acinetobacter baumannii in a mouse model of bacterial endophthalmitis