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If additional trials confirm that they effectively curb cravings across addictive substances, these drugs could begin to close one of the most consequential treatment gaps in medicine

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In contrast, long acting GLP-1 receptor agonists have relatively little effect on the rate of gastric emptying due to the development of tachyphylaxis resulting from continuous activation of the GLP-1 receptors in the GI tract (Nauck et al, 2011