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Effects on Food Intake and Metabolism From the outset, GLP-1 agonists were known to lower blood glucose by stimulating insulin secretion and reducing food intake

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The GLP-1R, as an integral membrane protein and 7-TMD GPCR, tightly interacts with its lipid-rich plasma membrane microenvironment (51) and is also known to segregate to cholesterol-rich flotillin-positive lipid nanodomains upon activation (25)