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Limited bioavailability and BBB penetration, reducing their central nervous system efficacy

2009: A study found that taking 1 gram of acetyl-L-carnitine twice daily for 6 months lowered systolic blood pressure by approximately 8 mmHg compared to baseline

Finally, NAC supports the Nrf2-dependent transcription pathway, a genetic cellular defense mechanism that upregulates the production of endogenous antioxidant enzymes, providing a robust buffer against the oxidative damage to DNA, proteins, and lipids that naturally occurs with aging and chronic illness