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The impaired cross-talk between dysfunctional endothelial cells and fibroblasts further compromises angiogenesis, as endothelial cells provide critical paracrine signals (such as PDGF-BB) that recruit and activate fibroblasts, while fibroblasts produce VEGF and deposit the ECM scaffold necessary for endothelial tube formation
Dietary implications on TMAO are clear
doi: 10.1038/s41388-017-0093-z 86 SchumannTAdhikaryTWortmannAFinkernagelFLieberSSchnitzerEet al
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