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In 2013, the creation of the first PET-suitable radiotracer, [ 18 F]UCB-H, allowed the in vivo measurement of changes in SV2A brain levels in both humans and animals (Warnock et al., 2014

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NNMT inhibition increases intracellular NAD+ by blocking nicotinamide methylation, but the long-term metabolic consequences of sustained NNMT suppression

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