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Since the medication causes glucose-dependent insulin release and did not cause hypoglycemia but suppressed appetite, liraglutide and semaglutide were both approved for weight loss in patients without diabetes [33, 34]

In a clinical trial involving obese individuals with knee osteoarthritis, semaglutide was associated with a greater improvement in an osteoarthritis index score

Emerging evidence suggests interventions like PPD may improve the endometrial environment by upregulating progesterone receptors, downregulating estrogen receptors, and normalizing immune cell function including reducing pro-inflammatory cytokines (IL-12, IFN-) in macrophages and enhancing decidual NK cell-mediated immune tolerance and angiogenesis ( 3.3 Tubal and anatomical factors Anatomical distortions caused by adhesions and fibrosis represent key contributors to infertility in endometriosis, leading to mechanical obstruction and impaired pelvic anatomy relevant to reproductive function