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Although no medication is specifically approved to treat IR, we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity

If appetite suppression makes eating enough protein difficult, collagen peptide supplements can help bridge the gap without requiring large meals

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Furthermore, the Endocrine Societys obesity guideline recommends that patients with obesity in the absence of diabetes should discontinue weight-loss medications if safety or tolerability issues arise, and consider other therapeutic options

Editorial and administrative support for this manuscript was provided by S
