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Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress

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Diabetes 52(2):380386 Lau J, Bloch P, Schffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM (2015) Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

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FIGURE 10 Notably, SR18 also contains a potential trypsin cleavage site (Figure 10), and the HRMS data (Supplementary Figure S7) with a peak around 685 Da confirm that trypsin can cleave SR18 between Lys17 and Ala18, leaving the remaining crucial 17 residues intact