May reverse early-stage uremia by enhancing nitrogenous waste clearance
The local GI argument is the strongest case for capsules, but it is rarely explained correctly If BPC-157 is degraded locally in the gut lumen and acts on GI epithelial receptors before degradation, then high oral bioavailability is not required for a GI-local effect
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Additionally, disruptions in the blood-brain barrier in those with neurocognitive symptoms have been observed, as well as hypoperfusion in various organs, contributing to end-organ dysfunction [364, 365]
Yan D, Ikeda TP, Shauger AE, Kustu S: Glutamate is required to maintain the steady-state potassium pool in Salmonella typhimurium