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Early research on Retatrutide showed participants losing up to 24% of their body weight over 48 weeks at the highest dose
Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study
These studies showed little to no co-expression GLP-1Rs and dopamine cell markers in the VTA 47,48 and high co-expression of GLP-1Rs and GABA cell markers throughout the mesolimbic reward system 47
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