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Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential

The follow-up plan, with its rationale and safety-net instructions, allows the result to be acted on consistently over time

In the Tau-P301L transgenic zebrafish model, significant down-regulation of BDNF is observed, which occurs in a TrkB receptor-independent manner at as early as 48 h after the Tau-P301L zebrafish embryos are fertilized [184]

Depending on the extent of size modulation observed, they were further graded