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Bottom Line GLP-1 medications can stay in your system anywhere from a day to a week, depending on the type, dose, and individual factors like metabolism and organ function

You may notice changes in bowel habits, mild nausea (particularly after meals), or a sensation of fullness that persists longer than usual

This should raise a red flag. Living up to the hype While experts caution against overusing GLP-1RAs or viewing them as a universal cure-all for obesity, physicians and researchers agree that the drugs are highly effective for weight management and Type 2 diabetes treatment

The Beneficial Effects of a Paleolithic Diet on Type 2 Diabetes and Other Risk Factors for Cardiovascular Disease

Jerremalm et al., 2006