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Aberrant K63-linked ubiquitination disrupts intracellular signaling networks and autophagic flux, contributing to the accumulation of toxic protein species and impaired stress responses

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The methylation profile of the tumor was compared with previously defined methylation classes using the publicly available database of the German Center for Cancer Research (DKFZ) (Figure 4A) (Figure 4B) ( Figure 4 Interestingly, the sarcoma classifier showed a match in the primary tumor for soft tissue clear cell sarcoma (Score: 0.96), but EWSR1/CREB1 or ATF1 gene fusion were excluded

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