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(1) As per Joseph C Reynolds et al., Mitochondria are chief metabolic organelles with strong implications in cell aging that also coordinate broad physiological functions, in part, using peptides that are encoded within their independent genome. (4) The peptide endogenous expression has also been posited to be boosted via physical activity, potentially enhancing cellular metabolism

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There are two main types of thyroid hormone receptors, TR and TR, which form homodimers or heterodimers with other nuclear receptor family members, the retinoid X receptors (RXRs) (Harvey et al