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While acute neuroinflammation can serve protective functions, dysregulated inflammatory processes are implicated in a host of neurodegenerative diseases, including Alzheimer's disease (AD) 1,2

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Graphical Abstract Similar content being viewed by others Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), with a steady upward trend in prevalence estimates from 25.3% in 19902006 to 38.2% in 20162019 [1], has become a leading cause of chronic liver disease worldwide [2,3,4], increasing the risk of both hepatic and extrahepatic complications, such as cardiovascular and chronic kidney diseases [5, 6]

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