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Without that signal, your body treats muscle as an expendable energy source, especially during significant weight loss

This alters the intended pharmacokinetics and may increase the risk of adverse effects

Now, when thinking about this many times well just say, Well, one of the strategies if I have someone who has OSA is weight loss. We recognize that if you look at some of the data, with every 1% change in weight, we expect to see a 2.6% reduction in AHI or apnea hypopnea index, so that is setting the standard already as to what the expectations are

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