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Against that background, the STEP 9 trial is especially important for KOA: among participants with obesity and moderate-to-severe knee pain, once-weekly semaglutide produced a mean body weight reduction of 13.7% versus 3.2% with placebo, together with a substantially greater improvement in WOMAC pain at 68 weeks (Bliddal et al., 2024)

doi: 10.1016/S2213-8587(15)00436-2 59 FrandsenCSDejgaardTFHolstJJAndersenHUThorsteinssonBMadsbadS

We employed an adeno-associated virus vector (AAV2/8) to deliver and express either human wild-type hepsin (hHPN WT

To address potential confounding factors, investigators also performed a propensity-matched analysis pairing GLP-1 users and non-users based on age, race, ethnicity, body mass index, breast density, and diabetes status