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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

Analytical size exclusion chromatography revealed a native molecular mass of 234,000 Da, which is in agreement with a tetrameric or a pentameric MDH architecture (Figure 2C)

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