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These pathways include MAPK, cGASSTING, phosphatidylinositol 3-kinase (PI3K)/AKT, Janus kinase (JAK)/ STAT, Wnt, transforming growth factor-beta (TGF-), Notch, and Hedgehog signaling, as well as signal transduction mediated by PRRs in innate immunity

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5 The 2018 update focused heavily on the use of glucose-lowering agents to mitigate cardiovascular and renal risks in the context of meeting individualized glycemic goals

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