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Individuals receiving therapeutic B12 injections or taking high-dose oral supplements without medical supervision face the greatest risk of very high levels
Selecting the Right Syringe Size Choose a syringe size appropriate for your dose volume
If symptoms of tiredness do not improve after 68 weeks of appropriate treatment, patients should contact their GP, as this may indicate an alternative or additional cause requiring investigation
But as you saw, the scientific literature shows that treatment with massive doses of B12, leading to very high blood levels, is 100% safe
This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice
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