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State and federal policymakers are increasingly responding to the issue, including new legislation introduced in Kentucky following a case in which a patient suffered acute liver failure requiring a transplant after taking a compounded weight-loss medication

Systemic Anti-Inflammatory Effects Patients with chronic inflammation, autoimmune conditions, or systemic pain syndromes have shown interest in the potential anti-inflammatory properties of both peptides Clinical Perspective: While patient motivations are valid, it is essential that expectations are calibrated to current evidence

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Market Dynamics and Growth Prospects The dramatic weight loss results achieved with GLP-1 agonistsoften between 15-25%have spurred market growth, far surpassing the performance of earlier medications

doi:10.1038/s41419-017-0217-y 74