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In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)
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GLP-1 agonists: act on the metabolism upstream by extrahepatic path The emergence of glucagon-like peptide-1 (GLP-1) agonists as a treatment option for diabetes and obesity has prompted their examination in patients with MASH 5
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