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Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic
Whilst animal studies raised concerns about thyroid tumours, these findings have not been replicated in human populations over follow-up periods of 25 years
It drives physical development, builds muscle, and controls sex drive, primarily in males, but it also supports health in females
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