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Many wellness brands market glutathione supplements as anti-aging and weight-loss aids, but clinical evidence for oral glutathione supplementation remains limited
Contamination Risks: Unregulated production increases the chance of contamination with harmful substances
We suggest that pregnant and lactating women talk to their healthcare providers
10.1093/oxfordjournals.bmb.a072641 92 RantforsJ.CassutoJ
Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency
