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The review highlights FOXO4-DRI's unique mechanism as a peptide-based senolytic with high selectivity for senescent cells, while noting challenges for clinical translation including peptide delivery and stability

10.1016/j.jpsychires.2019.10.006 19 LavignaG.MasoneA.BouybayouneI.BertaniI.LucchettiJ.GobbiM.et al (2021)

It is not FDA-approved for any indication, which means it exists in a regulatory gray area in many jurisdictions