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Even if berberine does increase endogenous GLP-1 levels to some degree, this indirect effect is mechanistically and clinically distinct from the direct receptor agonism provided by pharmaceutical GLP-1 agonists

Recommended treatment should be repeated for a 3-6 month period

At the time of analysis, median duration of response in this subgroup had not been reached

These numbers are meaningfully higher than tirzepatide discontinuation rates and represent an important consideration for researchers planning long-term protocols

Zandvoort A, Postma DS, Jonker MR, Noordhoek J, Vos JTWM, van der Geld YM, Timens W: Altered expression of the Smad signalling pathway: implications for COPD pathogenesis