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Indicated concentrations of APR-246 were added and after 60 min incubation, 6 M fluorescein isothiocyanate coupled to insulin (FITC-insulin) was added to start the reaction 31
10.1016/j.rbp.2011.12.001 Braz J Psychiatry
However, in vivo studies primarily in humans are needed to confirm these promising preclinical findings
Use the same instincts you have developed as a consumer to make judgments about potential "hype." Ask about the evidence behind a treatment, realizing that while randomized controlled clinical trials are the highest level of evidence, they are challenging to conduct in individuals with ASD.
If the individual is experiencing symptoms of hyperglycemia such as increased urination or thirst or unintentional weight loss along with very high blood sugar, insulin is typically indicated (Feingold 2000
