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Shape engineering, such as rod-like versus spherical particles, can enhance membrane contact and cellular uptake, while stimuli-responsive materials (e.g., ROS- or pH-sensitive polymers) enable on-demand drug release at RIRI lesions, reducing off-target effects

Supplementary information, Fig

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That makes oral drug delivery a challenge

Practical next steps clinicians typically recommend include checking blood sugar control, testing vaginal discharge to distinguish yeast from bacterial vaginosis or other causes, treating confirmed Candida with topical or oral antifungals, and addressing contributing factors such as dehydration, antibiotic use, or changes in estrogen status