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385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage
Patients with active cancer, certain bleeding disorders, pregnancy, or untreated systemic conditions are not candidates regardless of how strong the recovery interest is
Trial registration: clinicaltrials.gov: NCT03071666
FEBS Open Bio
J Pediatr 161:531535
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