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60,61 Overview of ferroptosis Ferroptosis is a cellular response to oxidative stress that depends on excess iron, phospholipids (PLs) with polyunsaturated fatty acid chains (PUFAs), and ROS

This condition develops when too much fat builds up in the liver and is not caused by alcohol [6]

(A) Cells were pretreated with or without GLP-1 (10 nM) for 1 h in the presence or absence of Ex-9 (10 nM) and incubated with H 2 O 2 (1 mM) for 12 h, HDAC6 were detected by immunofluorescence analysis

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Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS