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Risk assessment should consider patient age, smoking history, and presence of constitutional symptoms

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So far, the largest molecule known to cross the BBB through a nonsaturated mechanism (active transport or specific receptor-mediated pathways rather than passive diffusion) is CINC-1, a cytokine involved in regulating inflammation and immune responses, with a molecular weight of 7.8 kDa

This rapid reversibility makes the treatment relatively low-risk for trying: if you experience unmanageable symptoms, your healthcare provider can pause therapy and reassess your approach