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An invited commentary on this study, also published in JAMA Ophthalmology, challenges the idea that the increased risk of NAION among semaglutide users resulted directly from the medication

Its unique profile (native gastric peptide, stable without carriers, effective at nanogram doses, modulating multiple interconnected neurotransmitter systems simultaneously, promoting actual neuronal repair rather than just symptomatic relief) distinguishes it from all existing psychiatric medications

Kunutsor SK, Seidu S, Dey RS, Baidoo IK, Oulhaj A

Clear or very pale blue might mean insufficient copper binding or extremely dilute concentrations

Similar results were reported in a recent retrospective study on post-MBS patients who were prescribed semaglutide or liraglutide after 8 years [47]