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As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]
10.1093/ndt/16.7.1483 Guillaume CP, Stolk L, Dejagere TF, Kooman JP: Successful use of hemodialysis in acute valproic acid intoxication
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