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215 In addition, mitochondrial STAT3 limits excessive ROS production, thereby curbing ROS-induced mitophagy

In the brain, it acts on appetite centers in the hypothalamus, directly reducing hunger signals and food cravings

Interestingly, in a 21% O 2 atmosphere the cytotoxic effect of Ru(II)-OH, NP2, and NP4 was found to be in the same range (IC 50 = 6.110.4 M)

To our best knowledge, this is the first systematic review to address these gaps by synthesizing evidence in CAD patients across mechanistic markers such as oxidative stress, inflammatory mediators, autophagy-related markers and post-PCI myocardial-injury biomarkers together with clinical endpoints such as ventricular arrythmia, mortality and angina