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As a specific example: do these multi-agonists act simultaneously at multiple receptors residing at a single tissue or even a single cell

Nat Rev Endocrinol 8:728742 Gough SC, Bode B, Woo V et al (2014) Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

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The last decade has been characterized by a dramatic increase in the number of children diagnosed with ASD