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[15] GLP-1 has also shown signs of carrying out protective and regulatory effects in numerous other tissues, including heart, tongue, adipose, muscles, bones, kidneys, liver and lungs

Tell the liver to slow its glucose output

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The wider arc of those opening weeks is covered in what to expect in the first month on GLP-1, and slowing the titration pace is one of the most reliable levers, as discussed in the semaglutide dosing schedule