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The following will review recent evidence, including from the FLOW and SELECT trials, disclosing benefits of GLP-1 RAs, with a particular focus on kidney disease progression and cardiovascular benefits in patients with diabetes

Age is another major risk factor: HF has been reported to affect around 1%2% of all adults ( The pathophysiology of HF has been extensively reviewed by others ( As mentioned earlier, HF is traditionally considered as three main phenotypes: HFrEF, HFmrEF and HFpEF ( Currently available pharmacotherapeutics options in HF mostly remain focused on HFrEF, where treatments strategies aim at relief of symptoms, improving quality of life, and prolonging the life of the affected individual ( GLP-1 receptor agonism in heart failure Clinical evidence Only a few clinical investigations studying the effects of GLP-1 RAs specifically in HF (all in HFrEF) have been reported as briefly discussed below

Enhanced absorption

The greatest risk of death occurs during this period (most often related to cerebral edema)