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The results demonstrated that resveratrol administration decreased plasma levels of thyroid-stimulating hormone (TSH) as well as hypothalamic mRNA levels of thyrotropin-releasing hormone (TRH)
Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints
Clarifying compoundgut microbiota interactions and whether microbial metabolism enhances or limits therapeutic efficacy would strengthen the gutliver axis perspective
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