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Other gene mutations can affect function of the HPO axis and contribute to hormone imbalance

Though useful for accounting for study endpoint events in a rapidly fatal disease (i.e., death versus study completion versus trial withdrawal), combined outcomes suffer from issues with cross-trial validity and weighting the importance of relative contributions to outcome (death versus disease progression versus loss of follow-up) in creating the summed rank model [51]

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Degrees of skin erythema, induration, and scales were classified: 0, no symptoms

doi: 10.1111/j.1751-1097.2012.01186.x 50 MeyerP.Van de PoelB.De ConinckB