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This section focuses on the signaling mechanism of GLP1R in the pancreas

The heartburn comes from acid reaching the esophagus through a mechanical process (delayed emptying plus increased pressure), not from any toxic or erosive effect on stomach tissue

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All clinical confidence ratings above apply to human outcomes, not animal findings

Approved by the MHRA and available on NHS prescription, Trulicity offers effective glycaemic control alongside potential cardiovascular benefits and modest weight management support when used as part of a comprehensive diabetes treatment plan