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This places them at elevated risk for B12 deficiency, and standard oral supplementation may not provide adequate absorption

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Intervention safety optimization involves leveraging engineered bacteria (with gene editing for precise metabolic pathway control) and multi-omics predictive models to forecast HF deterioration risk, providing molecular evidence for clinical alerts (Liu et al., 2022

Special vitamin B12 requirements during pregnancy, breastfeeding and in old age Pregnant women and breastfeeding mothers also have a higher requirement and must pay particular attention to getting enough vitamin B12, preferably through their normal diet

The DEGs were significantly enriched in metabolic pathways, protein digestion and absorption, retinol metabolism, MAPK signaling pathway, PI3KAkt signaling pathway, Wnt signaling pathway, PPAR signaling pathway, and TGF-beta signaling pathway (Figure 4A)