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Oxidative stress occurs when theres an imbalance between the production of free radicals and the bodys ability to fight them off

Morning cortisol peaks between 69 AM directly inhibit GH receptor signaling in target tissues, reducing downstream IGF-1 synthesis even when serum GH levels rise

Novo Nordisk - Regulatory Approval (December 2025): FDA approved the first oral GLP-1 for weight loss-Novo Nordisk's once-daily semaglutide pill-which launched in January 2026 [3]

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Taken together, these findings suggest GLP-1 RAs could broaden the therapeutic toolkit for HS, particularly for patients with concomitant obesity, and potentially even for those without, via anti-inflammatory effects