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sygl-1 (synthetic Glp, T27F6.4), based on mRNA in situ data showing expression within the GSC pool ( sygl-1 and other candidate target genes were performed ( sygl-1 and lst-1 (lateral signaling target 1) knockdown, resulted in a Glp phenotype during larval development ( lst-1 sygl-1 double mutant and found to phenocopy a loss of glp-1 ( lst-1 or sygl-1 alone results in relatively wild-type germlines with an intact progenitor zone ( lst-1 and sygl-1 are also required to promote GSC proliferation in adults, as reduction in both lst-1 and sgyl-1 in adults via double RNAi results in a loss of the GSC pool ( lst-1 and sygl-1 are likely the only direct target genes of GLP-1/Notch signaling that regulate this balance ( Both lst-1 and sygl-1 appear to be conserved only within the Caenorhabditis genus ( The progenitor zone is slightly reduced, as compared to wild-type, in lst-1 single mutants
27 It is well known that enteroendocrine cells produce low basal levels of GLP-1 during pre-prandial state, however after food ingestion the synthesis and secretion of GLP-1 sharply raises with a peak 3060 min following nutrient intake
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Repair, matrix, and tissue-model research references
Hall JO, Davis TZ, Gupta RC
