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This rationale aligns with emerging priorities in cardio-oncology, where patients treated with anthracyclines face substantial risk of cardiotoxicity and where metabolic interventions may be especially valuable, particularly in cancers such as breast, ovarian, and prostate, in which cachexia is uncommon but treatment-related weight gain is frequent 26,27

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The product of 5-LOX catalysis is 5-hydroperoxyeicosatrienoic acid (5-HEPTE)