semaglutide approved for mash FDA Approval Expands Novo Nordisk's Wegovy to the Fatty Liver Disease The Food and Drug Administration

Patients may also find their legs, feet, and ankles constantly swollen

If semaglutide alone reaches a plateau despite dose optimization, switching to a higher-potency compound may be necessary

These young growing rats, which increased in body weight over the course of 42-days, exhibited a less pronounced weight gain and a resulting lower body weight at the end of the study when receiving daily semaglutide (41 10% weight gain) compared to a saline control (65 13% weight gain) ( P = 0.0114, Table S6)

Ahren B, Pacini G, Foley JE, Schweizer A

The dopamine effect appears to reduce food-related reward signaling, particularly for sweet and high-fat foods